The laminin binding integrin α6β1 in prostate cancer perineural invasion
نویسندگان
چکیده
منابع مشابه
Characterization of Laminin Binding Integrin Internalization in Prostate Cancer Cells.
Laminin binding integrins α6 (CD49f) and α3 (CD49c) are persistently but differentially expressed in prostate cancer (PCa). Integrin internalization is an important determinant of their cell surface expression and function. Using flow cytometry, and first order kinetic modeling, we quantitated the intrinsic internalization rates of integrin subunits in a single cycle of internalization. In PCa ...
متن کاملPerineural Invasion and Risk of Lethal Prostate Cancer.
Background: Prostate cancer has a propensity to invade and grow along nerves, a phenomenon called perineural invasion (PNI). Recent studies suggest that the presence of PNI in prostate cancer has been associated with cancer aggressiveness.Methods: We investigated the association between PNI and lethal prostate cancer in untreated and treated prostate cancer cohorts: the Swedish Watchful Waiting...
متن کاملMechanistic basis for the recognition of laminin-511 by α6β1 integrin
Laminins regulate diverse cellular functions through interaction with integrins. Two regions of laminins-three laminin globular domains of the α chain (LG1-3) and the carboxyl-terminal tail of the γ chain (γ-tail)-are required for integrin binding, but it remains unclear how the γ-tail contributes to the binding. We determined the crystal structure of the integrin binding fragment of laminin-51...
متن کاملEvidence that Distinct States of the Integrin α6β1 Interact with Laminin and an ADAM
Integrins can exist in different functional states with low or high binding capacity for particular ligands. We previously provided evidence that the integrin alpha6beta1, on mouse eggs and on alpha6-transfected cells, interacted with the disintegrin domain of the sperm surface protein ADAM 2 (fertilin beta). In the present study we tested the hypothesis that different states of alpha6beta1 int...
متن کامل[Prognostic role of perineural invasion in prostate biopsy].
INTRODUCTION Despite tumour cell dissemination through the intraprostatic nervous system being considered as a prostate cancer progression mechanism, the significance of perineural invasion in prostate biopsies to predict extraprostatic extension and its use as a potential prognosis factor is controversial. MATERIALS AND METHODS Retrospective study carried out at an institution on 208 patient...
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ژورنال
عنوان ژورنال: Journal of Cellular Physiology
سال: 2010
ISSN: 0021-9541
DOI: 10.1002/jcp.22149